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| 温肾养肝方早期干预便秘对帕金森疾病修饰随机对照研究唐莉莉,陆艳,梁艳,陈畅,赵杨 |
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| 投稿时间：2017-12-19 录用日期：2018-01-14 |
| DOI： |
| 中文关键词: 颤病,温肾养肝方,疾病修饰 |
| 英文关键词: Parkinson’s disease Wenshenyanggan decoction Disease modification, |
| 基金项目:1.江苏省中医药管理局课题( No.YB2015060) ;2.江苏省南京市科技发展计划项目( No. 20160536) |
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| 中文摘要: |
| 目的：观察温肾养肝方早期干预便秘对帕金森疾病修饰的作用。方法：将68例患者(其中脱落6例)随机分为治疗组(32例,中药干预,抗帕金森药物不变)和对照组(30 例,常规治疗不变)。 观察时间为2月,对治疗前后两组以下评分做对比：帕金森病问卷-39( PDQ -39) 积分、非运动症状评分量表( NMSS)、左旋多巴等效日剂量(LED)、克利夫兰量表(CCS评分)、H-Y分期。结果：两组患者在性别、年龄等一般资料具有可比性( P ＞0.05)。治疗组治疗后 NMSS 、LED、H-Y评分较前下降(P ＜0.05)；治疗组治疗后 CCS评分、PDQ-39 评分下降明显,有显著统计学差异(P ＜ 0.01)；治疗组PAC-QoL(生理、社会心理、满意度、担忧)评分下降,前两项评分有统计学差异 ( P<0.05),后两组有显著统计学差异 ( P<0.01)。 |
| 英文摘要: |
| Objective: To evaluate the efficacy of Wenshenyanggan decoction in treatment of Parkinson "s disease by early intervention of constipation． Methods: 68 patients of PD were randomly assigned to two groups: 32 in the treatment group ( treated by both Wenshenyanggan decoction and western medicine) and 30 in the control group ( treated only by western medicine) . A course of treatment for both groups is 2 months. Non- motor symptoms score scale ( NMSS) , Parkinson’s disease questionnaire- 39(PDQ-39) score , Levodopa equivalent dose , Cleveland Scale (CCS score) and H-Y stage for efficacy evaluation were observed． Results :The differences between two groups in gender,age,duration of illness(H-Y stage,CCS score) have no statistically significant ( P>0.05) ． The difference between two groups in curative effect of NMSS 、LED、H-Y stage , has statistical significance ( P <0.05). After treatment, the scores of PAC-QoL (physiology, social psychology) were statistically significant (P <0.05), and the atisfaction、worry scores were significant statistical significance (P <0.01). Conclusion: Wenshenyanggan decoction could significantly delay the progress of Parkinson"s disease, and improve living quality of PD patients． |
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