| Objective: To observe the clinical effect of Tiaogan Yishen prescription on hepatorenal Yin deficiency type non-proliferative diabetic retinopathy.Method:A total of 136 patients with diabetic retinopathy were selected for hospital treatment. From May 2021 to May 2023, patients with diabetic retinopathy were successively enrolled in the group, grouped by random number table method. 68 patients in the basic group were given conventional Western medicine treatment, and 68 patients in the Tiaogan Yishen prescription group. The clinical efficacy of the basic group was compared with that of the Yifunshenfang group. The patients were evaluated before and after treatment for dry mouth, dizziness and headache, yellow urine, dim vision, dry mouth and pharynx, sore waist and knees, dry stool, dry eye, five irritations and heat. The best corrected visual acuity (BCVA) of the patients was detected, and the end-diastolic flow rate, resistance index and peak systolic flow rate of the central retinal artery were detected. The expressions of hypoxia inducible factor 1α (HIF-1α), late oxidized protein product (AOPP), stromal cell derived factor 1α (SDF-1α), insulin-like growth factor 1 (IGF-1) and glutathione peroxidase (GSH-Px) were detected.Results: The total effective rate of Tiaogan Yishen prescription group was 97.06%, the total effective rate of basic group was 85.29%, the total effective rate of Tiaogan Yishen prescription group was higher than that of basic group (P < 0.05). Tiaogan Yishen prescription group had dry mouth, dizziness and headache, yellow urine, dim vision, dry mouth and throat, sore waist and soft knees, dry stool, dry eyes, and five upset heat scores were lower than those in basic group (P < 0.05). BCVA of Tiaogan Yishen prescription group was higher than that of basic group (P < 0.05); The central retinal artery resistance index in Yifunshen prescription group was lower than that in basic group (P < 0.05), and the end-diastolic flow velocity and peak systolic flow velocity of central retinal artery in Tiaogan Yishen prescription group were higher than that in basic group (P < 0.05). The levels of HIF-1α, SDF-1α and IGF-1 in Tiaogan Yishen prescription group were lower than those in basic group (P < 0.05); The GSH-Px level of Tiaogan Yishen prescription group was higher than that of basic group (P<0.05), and the AOPP level of Tiaogan Yishen prescription group was lower than that of basic group (P<0.05).Conclusion: Tiaogan Yishen prescription can reduce the levels of HIF-1α, SDF-1α and IGF-1, improve retinal hemodynamics, reduce oxidative stress damage, alleviate clinical symptoms, improve visual acuity and clinical efficacy in the treatment of patients with liver and kidney Yin deficiency type non-proliferative diabetic retinopathy |
