| 李婷,王海瑞,郝允姗,陈丽亚,俞爱华,胡阳,曾庆文.中药熏蒸与湿敷治疗面部皮炎短期临床疗效对比[J].中医药学报,2022,50(): |
| 中药熏蒸与湿敷治疗面部皮炎短期临床疗效对比 |
| Comparison of Short-term Clinical Efficacy of the Treatment of the Facial Dermatitis with the Fumigation and Wet Application of the Traditional Chinese Medicine |
| 投稿时间：2021-05-30 录用日期：2021-09-19 |
| DOI： |
| 中文关键词: 中药熏蒸 面部皮炎 皮肤康洗液 临床观察,VISIA,TEWL |
| 英文关键词: Fumigation with Chinese Medicine Facial dermatitis PIFUKANG lotion Clinical observation VISIA TEWL |
| 基金项目:上海市卫计委中医薄弱领域专科建设项目(BR2K2016014)；上海市嘉定区医学重点学科建设项目(2020-jdyxzdxk-07)：上海市嘉定区中医药科研课题（2017-KY-ZYY-17） |
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| 中文摘要: |
| 目的:对比皮肤康洗液熏蒸与湿敷两种方法短程治疗面部皮炎的临床疗效。方法: 将63例面部皮炎患者随机分为两组。治疗组予皮肤康洗液熏蒸，对照组予皮肤康洗液湿敷，均1次/d，连续治疗3d。2组均同时口服咪唑斯汀片和外用透明质酸修护生物膜。观察治疗前后两组临床症状和体征积分、VISIA检测的红色区绝对分值、皮肤生理测试仪测量的红斑指数（Erythema index，EX）和经皮水丢失（Transepidermal water loss,TEWL）变化，评估临床疗效，并记录不良反应。结果: 治疗3d后，61例患者完成随访，其中治疗组31例，有效率70.97%，对照组30例，有效率46.67%，差异无统计学意义(χ2 =3.72，P>0.05)。治疗后2组患者的瘙痒、灼热、干燥/紧绷、刺痛、红斑、丘疹、水肿、脱屑和皮损面积积分，VISIA 红色区绝对分值、EX和TEWL均较本组治疗前明显下降，差异均有统计学意义（均P <0.05）。治疗后瘙痒、刺痛、皮损面积积分以及VISIA 红色区绝对分值和EX治疗组明显低于对照组，差异均有统计学意义（均P <0.05）。2组不良反应发生率差异无统计学意义（P>0.05)。结论: 皮肤康洗液2种治疗方法短期内均可以安全有效治疗面部皮炎，熏蒸法在改善瘙痒、刺痛、红色区绝对分值和EX方面优于湿敷法。 |
| 英文摘要: |
| Objective: To compare the clinical efficacy of the short-term treatment of the facial dermatitis with the local fumigation and wet application of the PIFUKANG Lotion. Methods: 63 patients with facial dermatitis were randomly divided into two groups. The treatment group was treated with local fumigation of PIFUKANG lotion and the control group was treated with wet application of PIFUKANG lotion respectively once a day for 3 days. Both groups were given mizolastine tablets and hyaluronic acid repairing biofilm together. Before and after treatment, the changes of the clinical symptoms and signs、 the absolute score of the red area detected by vision、the erythema index (Ex) and the transdermal water loss (TEWL) measured by the skin physiological tester were observed. After treatment, the clinical efficacy was evaluated, and side effects were recorded. Results : After 3 days of treatment, 61 cases completed the treatment, including 31 cases in the treatment group, with an effective rate of 70.97%, 30 cases in the control group, with an effective rate of 46.67%, the difference was not statistically significant (χ2 =3.72，P>0.05). After treatment, the scores of lesion area, erythema, papule, edema, desquamation, pruritus, burning, dryness and tingling, the absolute score of VISIA red area, EX and TEWL in the two groups were significantly lower than those before treatment（all P < 0.05). In addition, after treatment, the scores of pruritus, tingling and lesion area, the absolute score of VISIA red area and EX in the treatment group were significantly lower than those in the control group, the differences were statistically significant (all P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).Conclusion: Both of the two methods are safe and effective in the treatment of facial dermatitis, but fumigation therapy of PIFUKANG lotion is better than the wet compress method in the improvement of pruritus, tingling, absolute score of red area and EX. |
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