| 吴鑫宇,关子赫,张婷婷,周雪明.大补阴丸治疗2型糖尿病合并骨关节炎的实验研究[J].中医药学报,2022,50(): |
| 大补阴丸治疗2型糖尿病合并骨关节炎的实验研究 |
| Experimental Study of Dabuyinwan in Treating Type 2 Diabetes with Osteoarthritis |
| 投稿时间：2021-06-09 录用日期：2021-09-10 |
| DOI： |
| 中文关键词: 大补阴丸 2型糖尿病 骨关节炎 实验研究 |
| 英文关键词: Dabuyinwan type 2 diabetes osteoarthritis experimental study |
| 基金项目:黑龙江省自然科学基金YQ2020H027；黑龙江省博士后特别资助LDH-Z18246 |
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| 中文摘要: |
| 目的：观察大补阴丸对2型糖尿病合并骨关节炎大鼠的治疗作用。方法：50只雄性SD大鼠，随机分为5组，每组10只，分别为空白组、模型组、阳性药组、大补阴丸高剂量组、大补阴丸低剂量组，连续给药6周。检测各组大鼠第0周、2周、4周、6周的血糖，骨关节中基质金属蛋白酶-3（MMP-3）含量，关节液中白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）及转化生长因子-β1（TGF-β1） mRNA表达量。结果：大补阴丸可降低实验大鼠血糖，给药组与模型组比较差异具有统计学意义（P ＜0.01）。大补阴丸可抑制骨关节中异常增多的MMP-3，减少关节液中IL-6、TNF-α及TGF-β1 mRNA表达，给药组与模型组比较差异具有统计学意义（P ＜0.01或P ＜0.05）。结论：大补阴丸可通过有效平稳地降低大鼠血糖，减低骨关节中MMP-3含量，减少关节液中IL-6、TNF-α及TGF-β1 mRNA表达量，从而控制血糖抑制炎症反应，发挥治疗2型糖尿病合并骨关节炎的作用。 |
| 英文摘要: |
| Objective: To observe the therapeutic effect of Dabuyinwan on type 2 diabetes and osteoarthritis rats. Methods: Fifty male SD rats were randomly divided into 5 groups, each with 10 rats, which were blank group, model group, positive drug group, Dabuyinwan high-dose group and Dabuyinwan low-dose group, continuously administered for 6 weeks. The blood sugar of rats in each group was measured at 0, 2, 4, and 6 weeks. Detect the content of matrix metalloproteinase-3 (MMP-3) in joint. Detection of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and transforming growth factor-β1 (TGF-β1) mRNA expression in synovial fluid. Results: Dabuyinwan can reduce blood sugar, and the difference between the administration group and the model group is statistically significant (P <0.01). Dabuyinwan can inhibit the abnormal increase of MMP-3 in arthrosis, and reduce the expression of IL-6, TNF-α and TGF-β1 mRNA. The difference between the administration group and the model group is statistically significant (P <0.01 or P <0.05). Conclusion: Dabuyinwan can effectively and steadily reduce blood sugar, reduce the content of MMP-3 in bone and joint, reduce the expression of IL-6, TNF-α and TGF-β1 mRNA in synovial fluid, thereby controlling blood sugar and inhibiting inflammation, thereby exerting treatment 2 Type diabetes with osteoarthritis. |
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